Frequenty Asked Questions

FAQ's

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Starting Ryeqo

What are the dosing requirements of Ryeqo?

One tablet of Ryeqo must be taken once daily, at around the same time each day, with or without food. Ryeqo can be taken without interruption.¹

When should patients start Ryeqo?

When starting treatment, the first tablet must be taken within 5 days of the onset of menstrual bleeding. If treatment is initiated on another day of the menstrual cycle, irregular and/or heavy bleeding may initially occur.Pregnancy must be ruled out prior to initiating treatment with Ryeqo.¹

What is the recommended duration of Ryeqo treatment?

Treatment recommended to be limited to 24 months, with extension of therapy conditional on stability of DXA and reassessment of risk/benefit in the individual patient by the treating physician.¹

What should you recommend if your patient misses a dose of Ryeqo?

If a dose is missed, treatment must be taken as soon as possible and then continue the next day at the usual time.If doses are missed for 2 or more consecutive days, a non-hormonal method of contraception is to be used for the next 7 days of treatment.¹

How should Ryeqo be stored?

Store at room temperature (below 30ºC).¹

Contraception and Fertility

Does Ryeqo reduce menstrual bleeding and if so, how many patients achieve amenorrhoea?

Ryeqo usually leads to a reduction in menstrual blood loss or amenorrhoea within the first 2 months of treatment.¹ After 24 weeks of Ryeqo treatment in clinical studies, amenorrhoea was achieved in 65.2% of patients with endometriosis and 51.6% of patients with uterine fibroids.¹At 52 weeks this number increased to 79.6% and 70.6%, respectively.^1–3

When is a patient’s fertility expected to return after stopping Ryeqo treatment?

Women of childbearing potential should be advised that ovulation will return rapidly after discontinuing treatment.A discussion with the patient, regarding appropriate contraceptive methods, must therefore take place prior to discontinuing treatment and alternative contraception needs to be started immediately after discontinuation of treatment.¹

Safety Considerations

Are there any side effects with Ryeqo that patients and prescribers should be aware of?

Ryeqo was generally well tolerated in clinical trials.^2,4The most common adverse drug reactions for patients being treated for endometriosis were headache (17.0%) and hot flush (11.7%).¹

What are the recommendations around bone health with Ryeqo use?

Assessment of bone mineral density via a DXA scan is recommended at baseline and then annually after starting treatment.Use of Ryeqo is recommended to be limited to 24 months, with extension of therapy conditional on stability of DXA and reassessment of risk/benefit in the individual patient by the treating physician.¹

In which patients is Ryeqo contraindicated?

Ryeqo is contraindicated in patients with: concomitant use of hormonal contraceptives; headaches with focal neurological symptoms or migraine headaches with aura; osteoporosis; pregnancy or breastfeeding; VTE/ATE (past or present); thrombophilic disorders; sex steroid influenced malignancies; liver tumours; severe hepatic disease; genital bleeding of unknown aetiology and hypersensitivity to active substances/excipients.¹

Symptom Improvements

How long until symptom improvements?

Many women see a significant effect on their symptoms as soon as four weeks. If it takes a little longer for your patient to see improvements, this is completely normal.^3,4

Abbreviations: ATE, arterial thromboembolism; DXA, dual X-ray absorptiometry; VTE, venous thromboembolism.

References

1. Ryeqo Approved Product Information. January 2024.
2. Becker CM et al. Human Reproduction. 2024;39(3):526–537.
3. Al-Hendy A et al. Obstet Gynecol. 2022;140:920–30.
4. Giudice LC et al. Lancet. 2022;399:2267–2279.