Ryeqo achieved sustained reduction in dysmenorrhoea over 2 years*1
*Bars show number of patients achieving a clinically meaningful response, which was defined as a mean reduction in NRS score of ≥2.8 for dysmenorrhoea.
†Placebo for 24 weeks and Ryeqo for 80 weeks. Adapted from Giudice et al. 2022 and Becker et al. 2024.1,2
Ryeqo offers sustained day-to-day pain reduction over 2 years1
†Placebo for 24 weeks and Ryeqo for 80 weeks. Adapted from Giudice et al. 2022 and Becker et al. 2024.1,2
Ryeqo achieved sustained reduction in NMPP over 2 years*1
*Bars show the number of patients achieving a clinically meaningful response, which was defined as a mean reduction in NRS score of ≥2.1 for NMPP.
†Placebo for 24 weeks and Ryeqo for 80 weeks. Adapted from Giudice et al. 2022 and Becker et al. 2024.1,2
Ryeqo offers sustained day-to-day pain reduction over 2 years1
†Placebo for 24 weeks and Ryeqo for 80 weeks. Adapted from Giudice et al. 2022 and Becker et al. 2024.1,2
Ryeqo delivered sustained reduction in overall pelvic pain over 2 years1
†Placebo for 24 weeks and Ryeqo for 80 weeks. Adapted from Becker et al. 2024.1
Ryeqo delivered sustained reduction in dyspareunia over 2 years1
†Placebo for 24 weeks and Ryeqo for 80 weeks. Adapted from Becker et al. 2024.1
75% of women were analgesic-free after 2 years of Ryeqo1
†Placebo for 24 weeks and Ryeqo for 80 weeks. *SPIRIT 2 data for patients not using analgesics for endometriosis-associated pain was from a post-hoc analysis. Adapted from Giudice et al. 2022 and Becker et al. 2024.1
91% of women were opioid-free after 2 years of Ryeqo1
†Placebo for 24 weeks and Ryeqo for 80 weeks. Adapted from Giudice et al. 2022 and Becker et al. 2024.1,2
Ryeqo reduced the effect of pain on daily activity over 2 years1
*Placebo for 24 weeks and Ryeqo for 80 weeks. †EHP-30 is a survey designed from the patient’s perspective to assess the effect of endometriosis-related pain on daily function and health-related quality of life. It assesses the effect of pain on normal daily activity including the ability to stand, sit, walk, exercise, sleep, to participate in social events and jobs, and the effect on appetite.2 Adapted from Becker et al. 2024.1

Error bars show upper limit of 95% confidence intervals.
Abbreviations: BL, baseline; CI, confidence interval; EHP30, Endometriosis Health Profile-30; LS, least squares; NMPP, non-menstrual pelvic pain; NRS, Numerical Rating Scale.
References
- Becker CM et al.Hum Reprod. 2024;39(3):526–537 (including Suppl Data).
- Giudice LC et al.Lancet. 2022;399:2267–2279.